Zdhhc13-dependent Drp1 S-palmitoylation impacts brain bioenergetics, anxiety, coordination and motor skills

Protein S-palmitoylation is a reversible post-translational modification mediated by palmitoyl acyltransferase enzymes, a group of Zn(2+)-finger DHHC-domain-containing proteins (ZDHHC). Here, for the first time, we show that Zdhhc13 plays a key role in anxiety-related behaviors and motor function, a...

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Detalles Bibliográficos
Autores principales: Napoli, Eleonora, Song, Gyu, Liu, Siming, Espejo, Alexsandra, Perez, Carlos J., Benavides, Fernando, Giulivi, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643561/
https://www.ncbi.nlm.nih.gov/pubmed/29038583
http://dx.doi.org/10.1038/s41598-017-12889-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643561/
https://www.ncbi.nlm.nih.gov/pubmed/29038583
http://dx.doi.org/10.1038/s41598-017-12889-0

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