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A systematic investigation of the maximum tolerated dose of cytotoxic chemotherapy with and without supportive care in mice
BACKGROUND: Cytotoxic chemotherapeutics form the cornerstone of systemic treatment of many cancers. Patients are dosed at maximum tolerated dose (MTD), which is carefully determined in phase I studies. In contrast, in murine studies, dosages are often based on customary practice or small pilot studi...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644108/ https://www.ncbi.nlm.nih.gov/pubmed/29037232 http://dx.doi.org/10.1186/s12885-017-3677-7 |