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Discovery of potent inhibitors of human β-tryptase from pre-equilibrated dynamic combinatorial libraries
Pre-equilibrated dynamic combinatorial libraries based on acyl hydrazone interchange of peptide-derived hydrazides and di- and tri-aldehydes have been used to discover potent inhibitors with nanomolar affinities for β-tryptase. To identify potent inhibitors the activity of the full library containin...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644118/ https://www.ncbi.nlm.nih.gov/pubmed/29163876 http://dx.doi.org/10.1039/c4sc02943g |