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Discovery of potent inhibitors of human β-tryptase from pre-equilibrated dynamic combinatorial libraries

Pre-equilibrated dynamic combinatorial libraries based on acyl hydrazone interchange of peptide-derived hydrazides and di- and tri-aldehydes have been used to discover potent inhibitors with nanomolar affinities for β-tryptase. To identify potent inhibitors the activity of the full library containin...

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Detalles Bibliográficos
Autores principales:	Jiang, Qian-Qian, Sicking, Wilhelm, Ehlers, Martin, Schmuck, Carsten
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2015
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644118/ https://www.ncbi.nlm.nih.gov/pubmed/29163876 http://dx.doi.org/10.1039/c4sc02943g

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