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ASXL gain-of-function truncation mutants: defective and dysregulated forms of a natural ribosomal frameshifting product?

BACKGROUND: Programmed ribosomal frameshifting (PRF) is a gene expression mechanism which enables the translation of two N-terminally coincident, C-terminally distinct protein products from a single mRNA. Many viruses utilize PRF to control or regulate gene expression, but very few phylogenetically...

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Detalles Bibliográficos
Autores principales: Dinan, Adam M., Atkins, John F., Firth, Andrew E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644247/
https://www.ncbi.nlm.nih.gov/pubmed/29037253
http://dx.doi.org/10.1186/s13062-017-0195-0