Effective modulation of stromal signaling through ROCK inhibition: Is it all in the timing?

Our recent publication demonstrates that transient inhibition of Rho-associated kinase signaling within stroma, significantly decreased in vivo primary tumor growth, metastasis and improved response to standard-of-care therapy in pancreatic cancer. Automated analysis of collagen organization in pati...

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Detalles Bibliográficos
Autores principales: Chin, Venessa T., Vennin, Claire, Timpson, Paul, Pajic, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644476/
https://www.ncbi.nlm.nih.gov/pubmed/29057302
http://dx.doi.org/10.1080/23723556.2017.1333973
Descripción
Sumario:Our recent publication demonstrates that transient inhibition of Rho-associated kinase signaling within stroma, significantly decreased in vivo primary tumor growth, metastasis and improved response to standard-of-care therapy in pancreatic cancer. Automated analysis of collagen organization in patient tumors may present a promising tool to predict response to our proposed treatment.

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