Effective modulation of stromal signaling through ROCK inhibition: Is it all in the timing?

Our recent publication demonstrates that transient inhibition of Rho-associated kinase signaling within stroma, significantly decreased in vivo primary tumor growth, metastasis and improved response to standard-of-care therapy in pancreatic cancer. Automated analysis of collagen organization in pati...

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Detalles Bibliográficos
Autores principales: Chin, Venessa T., Vennin, Claire, Timpson, Paul, Pajic, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644476/
https://www.ncbi.nlm.nih.gov/pubmed/29057302
http://dx.doi.org/10.1080/23723556.2017.1333973
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author Chin, Venessa T.
Vennin, Claire
Timpson, Paul
Pajic, Marina
author_facet Chin, Venessa T.
Vennin, Claire
Timpson, Paul
Pajic, Marina
author_sort Chin, Venessa T.
collection PubMed
description Our recent publication demonstrates that transient inhibition of Rho-associated kinase signaling within stroma, significantly decreased in vivo primary tumor growth, metastasis and improved response to standard-of-care therapy in pancreatic cancer. Automated analysis of collagen organization in patient tumors may present a promising tool to predict response to our proposed treatment.
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spelling pubmed-56444762018-05-26 Effective modulation of stromal signaling through ROCK inhibition: Is it all in the timing? Chin, Venessa T. Vennin, Claire Timpson, Paul Pajic, Marina Mol Cell Oncol Commentary Our recent publication demonstrates that transient inhibition of Rho-associated kinase signaling within stroma, significantly decreased in vivo primary tumor growth, metastasis and improved response to standard-of-care therapy in pancreatic cancer. Automated analysis of collagen organization in patient tumors may present a promising tool to predict response to our proposed treatment. Taylor & Francis 2017-05-26 /pmc/articles/PMC5644476/ /pubmed/29057302 http://dx.doi.org/10.1080/23723556.2017.1333973 Text en © 2017 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Commentary
Chin, Venessa T.
Vennin, Claire
Timpson, Paul
Pajic, Marina
Effective modulation of stromal signaling through ROCK inhibition: Is it all in the timing?
title Effective modulation of stromal signaling through ROCK inhibition: Is it all in the timing?
title_full Effective modulation of stromal signaling through ROCK inhibition: Is it all in the timing?
title_fullStr Effective modulation of stromal signaling through ROCK inhibition: Is it all in the timing?
title_full_unstemmed Effective modulation of stromal signaling through ROCK inhibition: Is it all in the timing?
title_short Effective modulation of stromal signaling through ROCK inhibition: Is it all in the timing?
title_sort effective modulation of stromal signaling through rock inhibition: is it all in the timing?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644476/
https://www.ncbi.nlm.nih.gov/pubmed/29057302
http://dx.doi.org/10.1080/23723556.2017.1333973
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