Alkylation and Carbamylation Effects of Lomustine and Its Major Metabolites and MGMT Expression in Canine Cells

DNA Alkylation is thought to be the reason for the efficacy of lomustine while carbamylation has been implicated as the cause for the side effects seen with lomustine treatment such as hepatotoxicity. In the alkylation study we show that lomustine and its metabolites form similar levels of the DNA a...

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Detalles Bibliográficos
Autores principales: Chakkath, Thushara, Lavergne, Sidonie, Fan, Timothy M., Bunick, David, Dirikolu, Levent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644621/
https://www.ncbi.nlm.nih.gov/pubmed/29061931
http://dx.doi.org/10.3390/vetsci2020052

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644621/
https://www.ncbi.nlm.nih.gov/pubmed/29061931
http://dx.doi.org/10.3390/vetsci2020052

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