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Myocilin Regulates Metalloprotease 2 Activity Through Interaction With TIMP3

PURPOSE: To elucidate functions of wild-type myocilin, a secreted glycoprotein associated with glaucoma. METHODS: Lysates of mouse eyes were used for immunoprecipitation with affinity-purified antibodies against mouse myocilin. Shotgun proteomic analysis was used for the identification of proteins i...

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Detalles Bibliográficos
Autores principales: Joe, Myung Kuk, Lieberman, Raquel L., Nakaya, Naoki, Tomarev, Stanislav I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644706/
https://www.ncbi.nlm.nih.gov/pubmed/29049729
http://dx.doi.org/10.1167/iovs.16-20336