Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-N (ε)-trimethyllysine

N (ε)-Trimethyllysine hydroxylase (TMLH) catalyses the first step in mammalian biosynthesis of carnitine, which plays a crucial role in fatty acid metabolism. The stereochemistry of the 3-hydroxy-N (ε)-trimethyllysine product of TMLH has not been defined. We report enzymatic and asymmetric synthetic...

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Detalles Bibliográficos
Autores principales: Leśniak, Robert K., Markolovic, Suzana, Tars, Kaspars, Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644716/
https://www.ncbi.nlm.nih.gov/pubmed/27965989
http://dx.doi.org/10.1039/c6cc08381a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644716/
https://www.ncbi.nlm.nih.gov/pubmed/27965989
http://dx.doi.org/10.1039/c6cc08381a

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