Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-N (ε)-trimethyllysine

N (ε)-Trimethyllysine hydroxylase (TMLH) catalyses the first step in mammalian biosynthesis of carnitine, which plays a crucial role in fatty acid metabolism. The stereochemistry of the 3-hydroxy-N (ε)-trimethyllysine product of TMLH has not been defined. We report enzymatic and asymmetric synthetic...

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Autores principales: Leśniak, Robert K., Markolovic, Suzana, Tars, Kaspars, Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644716/
https://www.ncbi.nlm.nih.gov/pubmed/27965989
http://dx.doi.org/10.1039/c6cc08381a
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author Leśniak, Robert K.
Markolovic, Suzana
Tars, Kaspars
Schofield, Christopher J.
author_facet Leśniak, Robert K.
Markolovic, Suzana
Tars, Kaspars
Schofield, Christopher J.
author_sort Leśniak, Robert K.
collection PubMed
description N (ε)-Trimethyllysine hydroxylase (TMLH) catalyses the first step in mammalian biosynthesis of carnitine, which plays a crucial role in fatty acid metabolism. The stereochemistry of the 3-hydroxy-N (ε)-trimethyllysine product of TMLH has not been defined. We report enzymatic and asymmetric synthetic studies, which define the product of TMLH catalysis as (2S,3S)-3-hydroxy-N (ε)-trimethyllysine.
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spelling pubmed-56447162017-11-21 Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-N (ε)-trimethyllysine Leśniak, Robert K. Markolovic, Suzana Tars, Kaspars Schofield, Christopher J. Chem Commun (Camb) Chemistry N (ε)-Trimethyllysine hydroxylase (TMLH) catalyses the first step in mammalian biosynthesis of carnitine, which plays a crucial role in fatty acid metabolism. The stereochemistry of the 3-hydroxy-N (ε)-trimethyllysine product of TMLH has not been defined. We report enzymatic and asymmetric synthetic studies, which define the product of TMLH catalysis as (2S,3S)-3-hydroxy-N (ε)-trimethyllysine. Royal Society of Chemistry 2017-01-07 2016-11-29 /pmc/articles/PMC5644716/ /pubmed/27965989 http://dx.doi.org/10.1039/c6cc08381a Text en This journal is © The Royal Society of Chemistry 2016 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Leśniak, Robert K.
Markolovic, Suzana
Tars, Kaspars
Schofield, Christopher J.
Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-N (ε)-trimethyllysine
title Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-N (ε)-trimethyllysine
title_full Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-N (ε)-trimethyllysine
title_fullStr Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-N (ε)-trimethyllysine
title_full_unstemmed Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-N (ε)-trimethyllysine
title_short Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-N (ε)-trimethyllysine
title_sort human carnitine biosynthesis proceeds via (2s,3s)-3-hydroxy-n (ε)-trimethyllysine
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644716/
https://www.ncbi.nlm.nih.gov/pubmed/27965989
http://dx.doi.org/10.1039/c6cc08381a
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