Evaluating the therapeutic potential of idebenone and related quinone analogues in Leber hereditary optic neuropathy

Leber hereditary optic neuropathy (LHON) is an important cause of mitochondrial blindness among young adults. In this study, we investigated the potential of four quinone analogues (CoQ(1), CoQ(10), decylubiquinone and idebenone) in compensating for the deleterious effect of the m.11778G>A mitoch...

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Detalles Bibliográficos
Autores principales: Yu-Wai-Man, Patrick, Soiferman, Devorah, Moore, David G., Burté, Florence, Saada, Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644719/
https://www.ncbi.nlm.nih.gov/pubmed/28093355
http://dx.doi.org/10.1016/j.mito.2017.01.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5644719/
https://www.ncbi.nlm.nih.gov/pubmed/28093355
http://dx.doi.org/10.1016/j.mito.2017.01.004

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