Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells

The PTPN22(R620W) single nucleotide polymorphism increases the risk of developing multiple autoimmune diseases including type 1 diabetes, rheumatoid arthritis and lupus. PTPN22 is highly expressed in antigen presenting cells (APCs) where the expression of the murine disease associated variant orthol...

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Detalles Bibliográficos
Autores principales: Clarke, Fiona, Jordan, Christine K., Gutiérrez-Martinez, Enrique, Bibby, Jack A., Sanchez-Blanco, Cristina, Cornish, Georgina H., Dai, Xuezhi, Rawlings, David J., Zamoyska, Rose, Guermonprez, Pierre, Cope, Andrew P., Purvis, Harriet A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645108/
https://www.ncbi.nlm.nih.gov/pubmed/29040339
http://dx.doi.org/10.1371/journal.pone.0186625

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645108/
https://www.ncbi.nlm.nih.gov/pubmed/29040339
http://dx.doi.org/10.1371/journal.pone.0186625

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