Mechanism of error-free replication across benzo[a]pyrene stereoisomers by Rev1 DNA polymerase

Benzo[a]pyrene (BP) is a carcinogen in cigarette smoke which, after metabolic activation, can react with the exocyclic N (2) amino group of guanine to generate four stereoisomeric BP-N (2)-dG adducts. Rev1 is unique among translesion synthesis DNA polymerases in employing a protein-template-directed...

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Detalles Bibliográficos
Autores principales: Rechkoblit, Olga, Kolbanovskiy, Alexander, Landes, Hannah, Geacintov, Nicholas E., Aggarwal, Aneel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645340/
https://www.ncbi.nlm.nih.gov/pubmed/29042535
http://dx.doi.org/10.1038/s41467-017-01013-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645340/
https://www.ncbi.nlm.nih.gov/pubmed/29042535
http://dx.doi.org/10.1038/s41467-017-01013-5

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