Structural analysis of PIM1 kinase complexes with ATP-competitive inhibitors

PIM1 is an oncogenic kinase overexpressed in a number of cancers where it correlates with poor prognosis. Several studies demonstrated that inhibition of PIM1 activity is an attractive strategy in fighting overexpressing cancers, while distinct structural features of ATP binding pocket make PIM1 an...

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Detalles Bibliográficos
Autores principales: Bogusz, Jozefina, Zrubek, Karol, Rembacz, Krzysztof P., Grudnik, Przemyslaw, Golik, Przemyslaw, Romanowska, Malgorzata, Wladyka, Benedykt, Dubin, Grzegorz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645348/
https://www.ncbi.nlm.nih.gov/pubmed/29042609
http://dx.doi.org/10.1038/s41598-017-13557-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645348/
https://www.ncbi.nlm.nih.gov/pubmed/29042609
http://dx.doi.org/10.1038/s41598-017-13557-z

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