Knockout of maternal CD163 protects fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV)

After infection of the porcine dam at about 90 days of gestation, porcine reproductive and respiratory syndrome virus (PRRSV) crosses the placenta and begins to infect fetuses. Outcomes of include abortion, fetal death and respiratory disease in newborn piglets. CD163 is the receptor for the virus....

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Autores principales: Prather, Randall S., Wells, Kevin D., Whitworth, Kristin M., Kerrigan, Maureen A., Samuel, Melissa S., Mileham, Alan, Popescu, Luca N., Rowland, Raymond R. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645351/
https://www.ncbi.nlm.nih.gov/pubmed/29042674
http://dx.doi.org/10.1038/s41598-017-13794-2
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author Prather, Randall S.
Wells, Kevin D.
Whitworth, Kristin M.
Kerrigan, Maureen A.
Samuel, Melissa S.
Mileham, Alan
Popescu, Luca N.
Rowland, Raymond R. R.
author_facet Prather, Randall S.
Wells, Kevin D.
Whitworth, Kristin M.
Kerrigan, Maureen A.
Samuel, Melissa S.
Mileham, Alan
Popescu, Luca N.
Rowland, Raymond R. R.
author_sort Prather, Randall S.
collection PubMed
description After infection of the porcine dam at about 90 days of gestation, porcine reproductive and respiratory syndrome virus (PRRSV) crosses the placenta and begins to infect fetuses. Outcomes of include abortion, fetal death and respiratory disease in newborn piglets. CD163 is the receptor for the virus. In this study, CD163-positive fetuses, recovered between 109 days of gestation or 20 days after maternal infection, were completely protected from PRRSV in dams possessing a complete knockout of the CD163 receptor. The results demonstrate a practical means to eliminate PRRSV-associated reproductive disease, a major source of economic hardship to agriculture.
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spelling pubmed-56453512017-10-26 Knockout of maternal CD163 protects fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV) Prather, Randall S. Wells, Kevin D. Whitworth, Kristin M. Kerrigan, Maureen A. Samuel, Melissa S. Mileham, Alan Popescu, Luca N. Rowland, Raymond R. R. Sci Rep Article After infection of the porcine dam at about 90 days of gestation, porcine reproductive and respiratory syndrome virus (PRRSV) crosses the placenta and begins to infect fetuses. Outcomes of include abortion, fetal death and respiratory disease in newborn piglets. CD163 is the receptor for the virus. In this study, CD163-positive fetuses, recovered between 109 days of gestation or 20 days after maternal infection, were completely protected from PRRSV in dams possessing a complete knockout of the CD163 receptor. The results demonstrate a practical means to eliminate PRRSV-associated reproductive disease, a major source of economic hardship to agriculture. Nature Publishing Group UK 2017-10-17 /pmc/articles/PMC5645351/ /pubmed/29042674 http://dx.doi.org/10.1038/s41598-017-13794-2 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Prather, Randall S.
Wells, Kevin D.
Whitworth, Kristin M.
Kerrigan, Maureen A.
Samuel, Melissa S.
Mileham, Alan
Popescu, Luca N.
Rowland, Raymond R. R.
Knockout of maternal CD163 protects fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV)
title Knockout of maternal CD163 protects fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV)
title_full Knockout of maternal CD163 protects fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV)
title_fullStr Knockout of maternal CD163 protects fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV)
title_full_unstemmed Knockout of maternal CD163 protects fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV)
title_short Knockout of maternal CD163 protects fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV)
title_sort knockout of maternal cd163 protects fetuses from infection with porcine reproductive and respiratory syndrome virus (prrsv)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645351/
https://www.ncbi.nlm.nih.gov/pubmed/29042674
http://dx.doi.org/10.1038/s41598-017-13794-2
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