Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder

Obsessive-compulsive disorder is a severe psychiatric disorder linked to abnormalities in glutamate signaling and the cortico-striatal circuit. We sequenced coding and regulatory elements for 608 genes potentially involved in obsessive-compulsive disorder in human, dog, and mouse. Using a new method...

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Detalles Bibliográficos
Autores principales: Noh, Hyun Ji, Tang, Ruqi, Flannick, Jason, O’Dushlaine, Colm, Swofford, Ross, Howrigan, Daniel, Genereux, Diane P., Johnson, Jeremy, van Grootheest, Gerard, Grünblatt, Edna, Andersson, Erik, Djurfeldt, Diana R., Patel, Paresh D., Koltookian, Michele, M. Hultman, Christina, Pato, Michele T., Pato, Carlos N., Rasmussen, Steven A., Jenike, Michael A., Hanna, Gregory L., Stewart, S. Evelyn, Knowles, James A., Ruhrmann, Stephan, Grabe, Hans-Jörgen, Wagner, Michael, Rück, Christian, Mathews, Carol A., Walitza, Susanne, Cath, Daniëlle C., Feng, Guoping, Karlsson, Elinor K., Lindblad-Toh, Kerstin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645406/
https://www.ncbi.nlm.nih.gov/pubmed/29042551
http://dx.doi.org/10.1038/s41467-017-00831-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645406/
https://www.ncbi.nlm.nih.gov/pubmed/29042551
http://dx.doi.org/10.1038/s41467-017-00831-x

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