AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway

DNA double-strand breaks (DSBs) are mainly repaired by either homologous recombination (HR) or non-homologous end-joining (NHEJ). Here, we identify AUNIP/C1orf135, a largely uncharacterized protein, as a key determinant of DSB repair pathway choice. AUNIP physically interacts with CtIP and is requir...

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Detalles Bibliográficos
Autores principales: Lou, Jiangman, Chen, Hongxia, Han, Jinhua, He, Hanqing, Huen, Michael S. Y., Feng, Xin-hua, Liu, Ting, Huang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645412/
https://www.ncbi.nlm.nih.gov/pubmed/29042561
http://dx.doi.org/10.1038/s41467-017-01151-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645412/
https://www.ncbi.nlm.nih.gov/pubmed/29042561
http://dx.doi.org/10.1038/s41467-017-01151-w

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