Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathology

Conventional genetic approaches and computational strategies have converged on immune-inflammatory pathways as key events in the pathogenesis of late onset sporadic Alzheimer’s disease (LOAD). Mutations and/or differential expression of microglial specific receptors such as TREM2, CD33, and CR3 have...

Descripción completa

Detalles Bibliográficos
Autores principales: Haure-Mirande, Jean-Vianney, Audrain, Mickael, Fanutza, Tomas, Kim, Soong Ho, Klein, William L., Glabe, Charles, Readhead, Ben, Dudley, Joel T., Blitzer, Robert D., Wang, Minghui, Zhang, Bin, Schadt, Eric E., Gandy, Sam, Ehrlich, Michelle E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645450/
https://www.ncbi.nlm.nih.gov/pubmed/28612290
http://dx.doi.org/10.1007/s00401-017-1737-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645450/
https://www.ncbi.nlm.nih.gov/pubmed/28612290
http://dx.doi.org/10.1007/s00401-017-1737-3

Ejemplares similares