Human iPSC-Derived Cerebellar Neurons from a Patient with Ataxia-Telangiectasia Reveal Disrupted Gene Regulatory Networks

Ataxia-telangiectasia (A-T) is a rare genetic disorder caused by loss of function of the ataxia-telangiectasia-mutated kinase and is characterized by a predisposition to cancer, pulmonary disease, immune deficiency and progressive degeneration of the cerebellum. As animal models do not faithfully re...

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Detalles Bibliográficos
Autores principales: Nayler, Sam P., Powell, Joseph E., Vanichkina, Darya P., Korn, Othmar, Wells, Christine A., Kanjhan, Refik, Sun, Jian, Taft, Ryan J., Lavin, Martin F., Wolvetang, Ernst J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645492/
https://www.ncbi.nlm.nih.gov/pubmed/29081736
http://dx.doi.org/10.3389/fncel.2017.00321

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645492/
https://www.ncbi.nlm.nih.gov/pubmed/29081736
http://dx.doi.org/10.3389/fncel.2017.00321

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