CoQ10 Augments Rosuvastatin Neuroprotective Effect in a Model of Global Ischemia via Inhibition of NF-κB/JNK3/Bax and Activation of Akt/FOXO3A/Bim Cues

Statins were reported to lower the Coenzyme Q10 (CoQ10) content upon their inhibition of HMG-CoA reductase enzyme and both are known to possess neuroprotective potentials; therefore, the aim is to assess the possible use of CoQ10 as an adds-on therapy to rosuvastatin to improve its effect using glob...

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Detalles Bibliográficos
Autores principales: Abd El-Aal, Sarah A., Abd El-Fattah, Mai A., El-Abhar, Hanan S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645536/
https://www.ncbi.nlm.nih.gov/pubmed/29081748
http://dx.doi.org/10.3389/fphar.2017.00735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645536/
https://www.ncbi.nlm.nih.gov/pubmed/29081748
http://dx.doi.org/10.3389/fphar.2017.00735

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