USP11 regulates PML stability to control Notch-induced malignancy in brain tumours

The promyelocytic leukaemia (PML) protein controls multiple tumour suppressive functions and is downregulated in diverse types of human cancers through incompletely characterized post-translational mechanisms. Here we identify USP11 as a PML regulator by RNAi screening. USP11 deubiquitinates and sta...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Hsin-Chieh, Lin, Yu-Ching, Liu, Cheng-Hsin, Chung, Hsiang-Ching, Wang, Ya-Ting, Lin, Ya-Wen, Ma, Hsin-I., Tu, Pang-Hsien, Lawler, Sean E., Chen, Ruey-Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645609/
https://www.ncbi.nlm.nih.gov/pubmed/24487962
http://dx.doi.org/10.1038/ncomms4214

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645609/
https://www.ncbi.nlm.nih.gov/pubmed/24487962
http://dx.doi.org/10.1038/ncomms4214

Ejemplares similares