Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes

[Image: see text] Valproic acid (VPA) is one of the most widely prescribed antiepileptic drugs in the world. Despite its pharmacological importance, it may cause liver toxicity and steatosis through mitochondrial dysfunction. The aim of this study is to further investigate VPA-induced mechanisms of...

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Detalles Bibliográficos
Autores principales: Wolters, Jarno E. J., van Breda, Simone G. J., Caiment, Florian, Claessen, Sandra M., de Kok, Theo M. C. M., Kleinjans, Jos C. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2017
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645762/
https://www.ncbi.nlm.nih.gov/pubmed/28853863
http://dx.doi.org/10.1021/acs.chemrestox.7b00171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5645762/
https://www.ncbi.nlm.nih.gov/pubmed/28853863
http://dx.doi.org/10.1021/acs.chemrestox.7b00171

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