Huntington’s Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits

Brain microvascular endothelial cells (BMECs) are an essential component of the blood-brain barrier (BBB) that shields the brain against toxins and immune cells. While BBB dysfunction exists in neurological disorders, including Huntington’s disease (HD), it is not known if BMECs themselves are funct...

Descripción completa

Detalles Bibliográficos
Autores principales: Lim, Ryan G., Quan, Chris, Reyes-Ortiz, Andrea M., Lutz, Sarah E., Kedaigle, Amanda J., Gipson, Theresa A., Wu, Jie, Vatine, Gad D., Stocksdale, Jennifer, Casale, Malcolm S., Svendsen, Clive N., Fraenkel, Ernest, Housman, David E., Agalliu, Dritan, Thompson, Leslie M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646270/
https://www.ncbi.nlm.nih.gov/pubmed/28514657
http://dx.doi.org/10.1016/j.celrep.2017.04.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646270/
https://www.ncbi.nlm.nih.gov/pubmed/28514657
http://dx.doi.org/10.1016/j.celrep.2017.04.021

Ejemplares similares