Functional improvement of dystrophic muscle by repression of utrophin: let-7c interaction

Duchenne muscular dystrophy (DMD) is a fatal genetic disease caused by an absence of the 427kD muscle-specific dystrophin isoform. Utrophin is the autosomal homolog of dystrophin and when overexpressed, can compensate for the absence of dystrophin and rescue the dystrophic phenotype of the mdx mouse...

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Detalles Bibliográficos
Autores principales: Mishra, Manoj K., Loro, Emanuele, Sengupta, Kasturi, Wilton, Steve D., Khurana, Tejvir S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646768/
https://www.ncbi.nlm.nih.gov/pubmed/29045431
http://dx.doi.org/10.1371/journal.pone.0182676

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646768/
https://www.ncbi.nlm.nih.gov/pubmed/29045431
http://dx.doi.org/10.1371/journal.pone.0182676

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