Rapamycin inhibits spermatogenesis by changing the autophagy status through suppressing mechanistic target of rapamycin-p70S6 kinase in male rats

Rapamycin (sirolimus) is an antiproliferative drug that has been widely used in the clinic as an immunosuppressant and a potential anticancer agent. Certain reports have indicated that rapamycin may induce male infertility through impairing sperm quality. The present study investigated the mechanism...

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Detalles Bibliográficos
Autores principales: Liu, Shangjing, Huang, Longxian, Geng, Yanqing, He, Junlin, Chen, Xuemei, Xu, Hao, Li, Rong, Wang, Yingxiong, Ding, Yubin, Liu, Xueqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646984/
https://www.ncbi.nlm.nih.gov/pubmed/28765938
http://dx.doi.org/10.3892/mmr.2017.7120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5646984/
https://www.ncbi.nlm.nih.gov/pubmed/28765938
http://dx.doi.org/10.3892/mmr.2017.7120

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