Up-regulation of casein kinase 1ε is involved in tau pathogenesis in Alzheimer’s disease

Hyperphosphorylation of tau and imbalanced expression of 3R-tau and 4R-tau as a result of dysregulation of tau exon 10 splicing are believed to be pivotal to the pathogenesis of tau pathology, but the molecular mechanism leading to the pathologic tau formation in Alzheimer’s disease (AD) brain is no...

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Detalles Bibliográficos
Autores principales: Chen, Caoyi, Gu, Jianlan, Basurto-Islas, Gustavo, Jin, Nana, Wu, Feng, Gong, Cheng-Xin, Iqbal, Khalid, Liu, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647372/
https://www.ncbi.nlm.nih.gov/pubmed/29044200
http://dx.doi.org/10.1038/s41598-017-13791-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647372/
https://www.ncbi.nlm.nih.gov/pubmed/29044200
http://dx.doi.org/10.1038/s41598-017-13791-5

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