Modeling and Preventing Progressive Hearing Loss in Usher Syndrome III

Usher syndrome type III (USH3) characterized by progressive loss of vision and hearing is caused by mutations in the clarin-1 gene (CLRN1). Clrn1 knockout (KO) mice develop hair cell defects by postnatal day 2 (P2) and are deaf by P21-P25. Early onset profound hearing loss in KO mice and lack of inf...

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Detalles Bibliográficos
Autores principales: Geng, Ruishuang, Omar, Akil, Gopal, Suhasini R., Chen, Daniel H.-C., Stepanyan, Ruben, Basch, Martin L., Dinculescu, Astra, Furness, David N., Saperstein, David, Hauswirth, William, Lustig, Lawrence R., Alagramam, Kumar N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647385/
https://www.ncbi.nlm.nih.gov/pubmed/29044151
http://dx.doi.org/10.1038/s41598-017-13620-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647385/
https://www.ncbi.nlm.nih.gov/pubmed/29044151
http://dx.doi.org/10.1038/s41598-017-13620-9

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