Cdk2 strengthens the intra-S checkpoint and counteracts cell cycle exit induced by DNA damage

Although cyclin-dependent kinase 2 (Cdk2) controls the G1/S transition and promotes DNA replication, it is dispensable for cell cycle progression due to redundancy with Cdk1. Yet Cdk2 also has non-redundant functions that can be revealed in certain genetic backgrounds and it was reported to promote...

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Detalles Bibliográficos
Autores principales: Bačević, Katarina, Lossaint, Gérald, Achour, Thiziri Nait, Georget, Virginie, Fisher, Daniel, Dulić, Vjekoslav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647392/
https://www.ncbi.nlm.nih.gov/pubmed/29044141
http://dx.doi.org/10.1038/s41598-017-12868-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647392/
https://www.ncbi.nlm.nih.gov/pubmed/29044141
http://dx.doi.org/10.1038/s41598-017-12868-5

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