Cargando…

Cdk2 strengthens the intra-S checkpoint and counteracts cell cycle exit induced by DNA damage

Although cyclin-dependent kinase 2 (Cdk2) controls the G1/S transition and promotes DNA replication, it is dispensable for cell cycle progression due to redundancy with Cdk1. Yet Cdk2 also has non-redundant functions that can be revealed in certain genetic backgrounds and it was reported to promote...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bačević, Katarina, Lossaint, Gérald, Achour, Thiziri Nait, Georget, Virginie, Fisher, Daniel, Dulić, Vjekoslav
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647392/ https://www.ncbi.nlm.nih.gov/pubmed/29044141 http://dx.doi.org/10.1038/s41598-017-12868-5

Ejemplares similares

Cdk-counteracting phosphatases unlock mitotic exit
por: Queralt, Ethel, et al.
Publicado: (2008)

Be quiet and you'll keep young: does mTOR underlie p53 action in protecting against senescence by favoring quiescence?
por: Dulic, Vjekoslav
Publicado: (2011)

Regulation of Mitotic Exit by Cell Cycle Checkpoints: Lessons From Saccharomyces cerevisiae
por: Matellán, Laura, et al.
Publicado: (2020)

Transient deSUMOylation of IRF2BP proteins controls early transcription in EGFR signaling
por: Barysch, Sina V, et al.
Publicado: (2021)

CDK6 Levels Regulate Quiescence Exit in Human Hematopoietic Stem Cells
por: Laurenti, Elisa, et al.
Publicado: (2015)

Spatiotemporal control of mitotic exit during anaphase by an aurora B-Cdk1 crosstalk
por: Afonso, Olga, et al.
Publicado: (2019)

Stress-mediated exit to quiescence restricted by increasing persistence in CDK4/6 activation
por: Yang, Hee Won, et al.
Publicado: (2020)

PKCɛ switches Aurora B specificity to exit the abscission checkpoint
por: Pike, Tanya, et al.
Publicado: (2016)

Checkpoint control of mitotic exit—do budding yeast mind the GAP?
por: Cooper, John A., et al.
Publicado: (2006)

Phosphorylation of Xenopus p31(comet) potentiates mitotic checkpoint exit
por: Mo, Min, et al.
Publicado: (2015)

Defects in the origin licensing checkpoint stresses cells exiting G0
por: Blow, J. Julian
Publicado: (2019)

The CDK Subunit CKS2 Counteracts CKS1 to Control Cyclin A/CDK2 Activity in Maintaining Replicative Fidelity and Neurodevelopment
por: Frontini, Mattia, et al.
Publicado: (2012)

Exiting the pandemic: Singapore style
por: Fisher, Dale, et al.
Publicado: (2021)

A virtual cycle: theory and experiment converge on the exit from mitosis
por: Merrick, Karl A, et al.
Publicado: (2010)

Pre-RC Protein MCM7 depletion promotes mitotic exit by Inhibiting CDK1 activity
por: Zheng, Dianpeng, et al.
Publicado: (2017)

Human Cdc14A regulates Wee1 stability by counteracting CDK-mediated phosphorylation
por: Ovejero, Sara, et al.
Publicado: (2012)

Exit from Mitosis in Budding Yeast: Protein Phosphatase 1 is Required Downstream from Cdk1 Inactivation
por: Keaton, Jason M., et al.
Publicado: (2023)

The atypical CDK activator RingoA/Spy1 regulates exit from quiescence in neural stem cells
por: Gonzalez, Laura, et al.
Publicado: (2023)

Cdk1 Phosphorylation of the Dam1 Complex Strengthens Kinetochore-Microtubule Attachments
por: Gutierrez, Abraham, et al.
Publicado: (2020)

Oleuropein Counteracts Both the Proliferation and Migration of Intra- and Extragonadal Seminoma Cells
por: Bossio, Sabrina, et al.
Publicado: (2022)

The NELF pausing checkpoint mediates the functional divergence of Cdk9
por: DeBerardine, Michael, et al.
Publicado: (2023)

DNA Repair Scaffolds Dampen Checkpoint Signaling by Counteracting the Rad9 Adaptor
por: Ohouo, Patrice Y., et al.
Publicado: (2012)

Getting to S: CDK functions and targets on the path to cell-cycle commitment
por: Fisher, Robert P.
Publicado: (2016)

Exit : imagen y cultura = Exit : image & culture

HDAC-inhibition counteracts everolimus resistance in renal cell carcinoma in vitro by diminishing cdk2 and cyclin A
por: Juengel, Eva, et al.
Publicado: (2014)

MAP Kinase Is Required for the Spindle Assembly Checkpoint but Is Dispensable for the Normal M Phase Entry and Exit in Xenopus Egg Cell Cycle Extracts
por: Takenaka, Katsuya, et al.
Publicado: (1997)

Weighted Correlation Network Analysis Reveals CDK2 as a Regulator of a Ubiquitous Environmental Toxin-Induced Cell-Cycle Arrest
por: Dubourg, Virginie, et al.
Publicado: (2020)

The CDK-activating kinase Cdk7: Taking yes for an answer
por: Schachter, Miriam Merzel, et al.
Publicado: (2013)

The Intra-S Checkpoint Responses to DNA Damage
por: Iyer, Divya Ramalingam, et al.
Publicado: (2017)

Recent advances in understanding the role of Cdk1 in the Spindle Assembly Checkpoint
por: Serpico, Angela Flavia, et al.
Publicado: (2020)

Mylohyoid foramen of mandible: a rare exit point of intra-mandibular origin of nerve to mylohyoid
por: Nayak, Satheesha B., et al.
Publicado: (2020)

Diacerein retards cell growth of chondrosarcoma cells at the G2/M cell cycle checkpoint via cyclin B1/CDK1 and CDK2 downregulation
por: Lohberger, Birgit, et al.
Publicado: (2015)

Improvement of Antitumor Therapies Based on Vaccines and Immune-Checkpoint Inhibitors by Counteracting Tumor-Immunostimulation
por: Chiarella, Paula, et al.
Publicado: (2018)

Targeting PPAR-gamma counteracts tumour adaptation to immune-checkpoint blockade in hepatocellular carcinoma
por: Xiong, Zhewen, et al.
Publicado: (2023)

Cdk9 regulates a promoter-proximal checkpoint to modulate RNA polymerase II elongation rate in fission yeast
por: Booth, Gregory T., et al.
Publicado: (2018)

CDK6 Degradation Is Counteracted by p16(INK4A) and p18(INK4C) in AML
por: Schmalzbauer, Belinda S., et al.
Publicado: (2022)

Cdc14 phosphatase counteracts Cdk-dependent Dna2 phosphorylation to inhibit resection during recombinational DNA repair
por: Campos, Adrián, et al.
Publicado: (2023)

Tem1 localization to the spindle pole bodies is essential for mitotic exit and impairs spindle checkpoint function
por: Valerio-Santiago, Mauricio, et al.
Publicado: (2011)

Exit México /
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_i56iq9csbs3n92s3bnqeebcv6u