Palmitate-induced lipotoxicity alters acetylation of multiple proteins in clonal β cells and human pancreatic islets

Type 2 diabetes is characterized by progressive β cell dysfunction, with lipotoxicity playing a possible pathogenetic role. Palmitate is often used to examine the direct effects of lipotoxicity and it may cause mitochondrial alterations by activating protein acetylation. However, it is unknown wheth...

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Detalles Bibliográficos
Autores principales: Ciregia, Federica, Bugliani, Marco, Ronci, Maurizio, Giusti, Laura, Boldrini, Claudia, Mazzoni, Maria R, Mossuto, Sandra, Grano, Francesca, Cnop, Miriam, Marselli, Lorella, Giannaccini, Gino, Urbani, Andrea, Lucacchini, Antonio, Marchetti, Piero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647430/
https://www.ncbi.nlm.nih.gov/pubmed/29044173
http://dx.doi.org/10.1038/s41598-017-13908-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647430/
https://www.ncbi.nlm.nih.gov/pubmed/29044173
http://dx.doi.org/10.1038/s41598-017-13908-w

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