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Angiotensin receptor blockade improves cardiac mitochondrial activity in response to an acute glucose load in obese insulin resistant rats

Hyperglycemia increases the risk of oxidant overproduction in the heart through activation of a multitude of pathways. Oxidation of mitochondrial enzymes may impair their function resulting in accumulation of intermediates and reverse electron transfer, contributing to mitochondrial dysfunction. Fur...

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Detalles Bibliográficos
Autores principales: Thorwald, Max, Rodriguez, Ruben, Lee, Andrew, Martinez, Bridget, Peti-Peterdi, Janos, Nakano, Daisuke, Nishiyama, Akira, Ortiz, Rudy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647524/
https://www.ncbi.nlm.nih.gov/pubmed/29049981
http://dx.doi.org/10.1016/j.redox.2017.10.005