Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action

The clinical development of anticancer metallodrugs is often hindered by the elusive nature of their molecular targets. To identify the molecular targets of an antimetastatic ruthenium organometallic complex based on 1,3,5-triaza-7-phosphaadamantane (RAPTA), we employed a chemical proteomic approach...

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Detalles Bibliográficos
Autores principales: Babak, Maria V., Meier, Samuel M., Huber, Kilian V. M., Reynisson, Jóhannes, Legin, Anton A., Jakupec, Michael A., Roller, Alexander, Stukalov, Alexey, Gridling, Manuela, Bennett, Keiryn L., Colinge, Jacques, Berger, Walter, Dyson, Paul J., Superti-Furga, Giulio, Keppler, Bernhard K., Hartinger, Christian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647740/
https://www.ncbi.nlm.nih.gov/pubmed/29308157
http://dx.doi.org/10.1039/c4sc03905j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647740/
https://www.ncbi.nlm.nih.gov/pubmed/29308157
http://dx.doi.org/10.1039/c4sc03905j

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