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Cis-regulatory elements explain most of the mRNA stability variation across genes in yeast

The stability of mRNA is one of the major determinants of gene expression. Although a wealth of sequence elements regulating mRNA stability has been described, their quantitative contributions to half-life are unknown. Here, we built a quantitative model for Saccharomyces cerevisiae based on functio...

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Detalles Bibliográficos
Autores principales: Cheng, Jun, Maier, Kerstin C., Avsec, Žiga, Rus, Petra, Gagneur, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648033/
https://www.ncbi.nlm.nih.gov/pubmed/28802259
http://dx.doi.org/10.1261/rna.062224.117