Rapid RNase L–driven arrest of protein synthesis in the dsRNA response without degradation of translation machinery

Mammalian cells respond to double-stranded RNA (dsRNA) by activating a translation-inhibiting endoribonuclease, RNase L. Consensus in the field indicates that RNase L arrests protein synthesis by degrading ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs). However, here we provide evidence for a dif...

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Detalles Bibliográficos
Autores principales: Donovan, Jesse, Rath, Sneha, Kolet-Mandrikov, David, Korennykh, Alexei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648034/
https://www.ncbi.nlm.nih.gov/pubmed/28808124
http://dx.doi.org/10.1261/rna.062000.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648034/
https://www.ncbi.nlm.nih.gov/pubmed/28808124
http://dx.doi.org/10.1261/rna.062000.117

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