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First-in-Man Evaluation of (124)I-PGN650: A PET Tracer for Detecting Phosphatidylserine as a Biomarker of the Solid Tumor Microenvironment
PURPOSE: PGN650 is a F(ab′)(2) antibody fragment that targets phosphatidylserine (PS), a marker normally absent that becomes exposed on tumor cells and tumor vasculature in response to oxidative stress and increases in response to therapy. PGN650 was labeled with (124)I to create a positron emission...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648081/ https://www.ncbi.nlm.nih.gov/pubmed/29037107 http://dx.doi.org/10.1177/1536012117733349 |