First-in-Man Evaluation of (124)I-PGN650: A PET Tracer for Detecting Phosphatidylserine as a Biomarker of the Solid Tumor Microenvironment

PURPOSE: PGN650 is a F(ab′)(2) antibody fragment that targets phosphatidylserine (PS), a marker normally absent that becomes exposed on tumor cells and tumor vasculature in response to oxidative stress and increases in response to therapy. PGN650 was labeled with (124)I to create a positron emission...

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Detalles Bibliográficos
Autores principales: Laforest, Richard, Dehdashti, Farrokh, Liu, Yongjian, Frye, Jennifer, Frye, Sarah, Luehmann, Hannah, Sultan, Deborah, Shan, Joseph S., Freimark, Bruce D., Siegel, Barry A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648081/
https://www.ncbi.nlm.nih.gov/pubmed/29037107
http://dx.doi.org/10.1177/1536012117733349

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