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Deletion of the NR4A nuclear receptor NOR1 in hematopoietic stem cells reduces inflammation but not abdominal aortic aneurysm formation

BACKGROUND: The NR4A3 orphan nuclear hormone receptor, NOR1, functions as a constitutively active transcription factor to regulate inflammation, proliferation, and cell survival during pathological vascular remodeling. Inflammatory processes represent key mechanisms leading to abdominal aortic aneur...

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Detalles Bibliográficos
Autores principales: Qing, Hua, Jones, Karrie L., Heywood, Elizabeth B., Lu, Hong, Daugherty, Alan, Bruemmer, Dennis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648424/
https://www.ncbi.nlm.nih.gov/pubmed/29047330
http://dx.doi.org/10.1186/s12872-017-0701-4