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Mouse embryonic stem cells can differentiate via multiple paths to the same state

In embryonic development, cells differentiate through stereotypical sequences of intermediate states to generate particular mature fates. By contrast, driving differentiation by ectopically expressing terminal transcription factors (direct programming) can generate similar fates by alternative route...

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Detalles Bibliográficos
Autores principales: Briggs, James Alexander, Li, Victor C, Lee, Seungkyu, Woolf, Clifford J, Klein, Allon, Kirschner, Marc W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648529/
https://www.ncbi.nlm.nih.gov/pubmed/28990928
http://dx.doi.org/10.7554/eLife.26945