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A Review of the Clinical Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Vedolizumab

Vedolizumab is a humanized anti-α(4)β(7) integrin monoclonal antibody that selectively blocks trafficking of memory T cells to inflamed gut tissue by inhibiting the α(4)β(7)-mucosal addressin cell adhesion molecule-1 (MAdCAM-1) interaction. Approved for treating patients with moderately to severely...

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Detalles Bibliográficos
Autores principales: Rosario, Maria, Dirks, Nathanael L., Milch, Catherine, Parikh, Asit, Bargfrede, Michael, Wyant, Tim, Fedyk, Eric, Fox, Irving
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648740/
https://www.ncbi.nlm.nih.gov/pubmed/28523450
http://dx.doi.org/10.1007/s40262-017-0546-0