Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates

Peptide macrocycles are promising therapeutic molecules because they are protease resistant, structurally rigid, membrane permeable, and capable of modulating protein–protein interactions. Here, we report the characterization of the dual function macrocyclase-peptidase enzyme involved in the biosynt...

Descripción completa

Detalles Bibliográficos
Autores principales: Czekster, Clarissa M., Ludewig, Hannes, McMahon, Stephen A., Naismith, James H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648786/
https://www.ncbi.nlm.nih.gov/pubmed/29051530
http://dx.doi.org/10.1038/s41467-017-00862-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648786/
https://www.ncbi.nlm.nih.gov/pubmed/29051530
http://dx.doi.org/10.1038/s41467-017-00862-4

Ejemplares similares