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Characterization of a dual function macrocyclase enables design and use of efficient macrocyclization substrates
Peptide macrocycles are promising therapeutic molecules because they are protease resistant, structurally rigid, membrane permeable, and capable of modulating protein–protein interactions. Here, we report the characterization of the dual function macrocyclase-peptidase enzyme involved in the biosynt...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648786/ https://www.ncbi.nlm.nih.gov/pubmed/29051530 http://dx.doi.org/10.1038/s41467-017-00862-4 |