Cargando…

Calmodulin dissociates the STIM1-Orai1 complex and STIM1 oligomers

Store-operated calcium entry (SOCE) is a major pathway for calcium ions influx into cells and has a critical role in various cell functions. Here we demonstrate that calcium-bound calmodulin (Ca(2+)-CaM) binds to the core region of activated STIM1. This interaction facilitates slow Ca(2+)-dependent...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xin, Wu, Guangyan, Yang, Yin, Fu, Shijuan, Liu, Xiaofen, Kang, Huimin, Yang, Xue, Su, Xun-Cheng, Shen, Yuequan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648805/ https://www.ncbi.nlm.nih.gov/pubmed/29051492 http://dx.doi.org/10.1038/s41467-017-01135-w

Ejemplares similares

The STIM1/Orai signaling machinery
por: Fahrner, Marc, et al.
Publicado: (2013)

A cholesterol-binding domain in STIM1 modulates STIM1-Orai1 physical and functional interactions
por: Pacheco, Jonathan, et al.
Publicado: (2016)

The Orai-1 and STIM-1 Complex Controls Human Dendritic Cell Maturation
por: Félix, Romain, et al.
Publicado: (2013)

STIM1 Phosphorylation at Y361 Recruits Orai1 to STIM1 Puncta and Induces Ca(2+) Entry
por: Yazbeck, Pascal, et al.
Publicado: (2017)

S417 in the CC3 region of STIM1 is critical for STIM1-Orai1 binding and CRAC channel activation
por: Yu, Tao, et al.
Publicado: (2023)

ATP depletion induces translocation of STIM1 to puncta and formation of STIM1–ORAI1 clusters: translocation and re-translocation of STIM1 does not require ATP
por: Chvanov, Michael, et al.
Publicado: (2008)

Orais and STIMs: physiological mechanisms and disease
por: Berna-Erro, A, et al.
Publicado: (2012)

Molecular mechanisms of STIM/Orai communication
por: Derler, Isabella, et al.
Publicado: (2016)

STIM and ORAI proteins in the nervous system
por: Kraft, Robert
Publicado: (2015)

Calcium store refilling and STIM activation in STIM- and Orai-deficient cell lines
por: Zheng, Sisi, et al.
Publicado: (2018)

STIM and Orai1 Variants in Store-Operated Calcium Entry
por: Rosado, Juan A., et al.
Publicado: (2016)

STIMs and Orai1 regulate cytokine production in spinal astrocytes
por: Gao, Xinghua, et al.
Publicado: (2016)

Functional Role of STIM-1 and Orai1 in Human Microvascular Aging
por: El Assar, Mariam, et al.
Publicado: (2022)

Complex role of STIM1 in the activation of store-independent Orai1/3 channels
por: Zhang, Xuexin, et al.
Publicado: (2014)

Melatonin Mediates Osteoblast Proliferation Through the STIM1/ORAI1 Pathway
por: Cao, Lili, et al.
Publicado: (2022)

In this issue of Channels: Special issue on STIM and Orai
por: Romanin, Christoph
Publicado: (2013)

SOAR and the polybasic STIM1 domains gate and regulate the Orai channels
por: Yuan, Joseph P., et al.
Publicado: (2009)

Expression of Concern: The Orai-1 and STIM-1 complex controls human dendritic cell maturation
Publicado: (2020)

STIM1 couples to ORAI1 via an intramolecular transition into an extended conformation
por: Muik, Martin, et al.
Publicado: (2011)

Conformational Changes in the Orai1 C-Terminus Evoked by STIM1 Binding
por: Tirado-Lee, Leidamarie, et al.
Publicado: (2015)

STIM1 dimers undergo unimolecular coupling to activate Orai1 channels
por: Zhou, Yandong, et al.
Publicado: (2015)

Expression of ORAI1 and STIM1 genes in blood of patients with pulmonary tuberculosis
por: Kolesova, Oksana, et al.
Publicado: (2021)

Expression of Orai1 and STIM1 in human oral squamous cell carcinogenesis
por: Wang, Yen-Yun, et al.
Publicado: (2022)

Ang II Promotes Cardiac Autophagy and Hypertrophy via Orai1/STIM1
por: Zheng, Chang-Bo, et al.
Publicado: (2021)

Orai1 and Orai3 in Combination with Stim1 Mediate the Majority of Store-operated Calcium Entry in Astrocytes
por: Kwon, Jea, et al.
Publicado: (2017)

The role of STIM and ORAI proteins in phagocytic immune cells
por: Demaurex, Nicolas, et al.
Publicado: (2016)

Cell-wide mapping of Orai1 channel activity reveals functional heterogeneity in STIM1-Orai1 puncta
por: Dynes, Joseph L., et al.
Publicado: (2020)

A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels
por: Yeung, Priscilla S-W, et al.
Publicado: (2023)

TRIC-A shapes oscillatory Ca(2+) signals by interaction with STIM1/Orai1 complexes
por: Shrestha, Niroj, et al.
Publicado: (2020)

STIM-Orai1 signaling regulates fluidity of cytoplasm during membrane blebbing
por: Aoki, Kana, et al.
Publicado: (2021)

STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel
por: Gudlur, Aparna, et al.
Publicado: (2014)

The STIM1-binding site nexus remotely controls Orai1 channel gating
por: Zhou, Yandong, et al.
Publicado: (2016)

Regulation of membrane ruffling by polarized STIM1 and ORAI1 in cortactin-rich domains
por: Lopez-Guerrero, Aida M., et al.
Publicado: (2017)

Regulation of Orai1/STIM1 mediated I(CRAC) by intracellular pH
por: Gavriliouk, D., et al.
Publicado: (2017)

Retraction: Melatonin mediates osteoblast proliferation through the STIM1/ORAI1 pathway
Publicado: (2023)

Photocrosslinking-induced CRAC channel-like Orai1 activation independent of STIM1
por: Maltan, Lena, et al.
Publicado: (2023)

Apoptotic Cells Trigger Calcium Entry in Phagocytes by Inducing the Orai1-STIM1 Association
por: Kim, Deokhwan, et al.
Publicado: (2021)

STIM1- and Orai1-mediated Ca(2+) oscillation orchestrates invadopodium formation and melanoma invasion
por: Sun, Jianwei, et al.
Publicado: (2014)

The Inhibitory Helix Controls the Intramolecular Conformational Switching of the C-Terminus of STIM1
por: Cui, Boyang, et al.
Publicado: (2013)

Stim and Orai proteins in neuronal Ca(2+) signaling and excitability
por: Moccia, Francesco, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_7ij0av7pf46numrqv8n0595768