NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance

The molecular mechanisms that couple glycolysis to cancer drug resistance remain unclear. Here we identify an ATP-binding motif within the NADPH oxidase isoform, NOX4, and show that ATP directly binds and negatively regulates NOX4 activity. We find that NOX4 localizes to the inner mitochondria membr...

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Detalles Bibliográficos
Autores principales: Shanmugasundaram, Karthigayan, Nayak, Bijaya K., Friedrichs, William E., Kaushik, Dharam, Rodriguez, Ronald, Block, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648812/
https://www.ncbi.nlm.nih.gov/pubmed/29051480
http://dx.doi.org/10.1038/s41467-017-01106-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648812/
https://www.ncbi.nlm.nih.gov/pubmed/29051480
http://dx.doi.org/10.1038/s41467-017-01106-1

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