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NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance
The molecular mechanisms that couple glycolysis to cancer drug resistance remain unclear. Here we identify an ATP-binding motif within the NADPH oxidase isoform, NOX4, and show that ATP directly binds and negatively regulates NOX4 activity. We find that NOX4 localizes to the inner mitochondria membr...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648812/ https://www.ncbi.nlm.nih.gov/pubmed/29051480 http://dx.doi.org/10.1038/s41467-017-01106-1 |