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Substrate recognition by two different P450s: Evidence for conserved roles in a common fold

Cytochrome P450 monooxygenases CYP101A1 and MycG catalyze regio- and stereospecific oxidations of their respective substrates, d-camphor and mycinamicin IV. Despite the low sequence homology between the two enzymes (29% identity) and differences in size and hydrophobicity of their substrates, the co...

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Detalles Bibliográficos
Autores principales: Tietz, Drew R., Colthart, Allison M., Sondej Pochapsky, Susan, Pochapsky, Thomas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648816/
https://www.ncbi.nlm.nih.gov/pubmed/29051575
http://dx.doi.org/10.1038/s41598-017-14011-w