Arginase Structure and Inhibition: Catalytic Site Plasticity Reveals New Modulation Possibilities

Metalloenzyme arginase is a therapeutically relevant target associated with tumor growth. To fight cancer immunosuppression, arginase activity can be modulated by small chemical inhibitors binding to its catalytic center. To better understand molecular mechanisms of arginase inhibition, a careful co...

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Detalles Bibliográficos
Autores principales: Mortier, Jérémie, Prévost, Julien R. C., Sydow, Dominique, Teuchert, Sabine, Omieczynski, Christian, Bermudez, Marcel, Frédérick, Raphaël, Wolber, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648838/
https://www.ncbi.nlm.nih.gov/pubmed/29051526
http://dx.doi.org/10.1038/s41598-017-13366-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648838/
https://www.ncbi.nlm.nih.gov/pubmed/29051526
http://dx.doi.org/10.1038/s41598-017-13366-4

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