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Arginase Structure and Inhibition: Catalytic Site Plasticity Reveals New Modulation Possibilities
Metalloenzyme arginase is a therapeutically relevant target associated with tumor growth. To fight cancer immunosuppression, arginase activity can be modulated by small chemical inhibitors binding to its catalytic center. To better understand molecular mechanisms of arginase inhibition, a careful co...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648838/ https://www.ncbi.nlm.nih.gov/pubmed/29051526 http://dx.doi.org/10.1038/s41598-017-13366-4 |