Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects

Tau pathology is associated with cognitive decline in Alzheimer’s disease, and missense tau mutations cause frontotemporal dementia. Hyperphosphorylation and misfolding of tau are considered critical steps leading to tauopathies. Here, we determine how motifs controlling conformational changes in th...

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Detalles Bibliográficos
Autores principales: Lathuilière, Aurélien, Valdés, Pamela, Papin, Stéphanie, Cacquevel, Matthias, Maclachlan, Catherine, Knott, Graham W., Muhs, Andreas, Paganetti, Paolo, Schneider, Bernard L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648870/
https://www.ncbi.nlm.nih.gov/pubmed/29051562
http://dx.doi.org/10.1038/s41598-017-13786-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648870/
https://www.ncbi.nlm.nih.gov/pubmed/29051562
http://dx.doi.org/10.1038/s41598-017-13786-2

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