Cargando…

Motifs in the tau protein that control binding to microtubules and aggregation determine pathological effects

Tau pathology is associated with cognitive decline in Alzheimer’s disease, and missense tau mutations cause frontotemporal dementia. Hyperphosphorylation and misfolding of tau are considered critical steps leading to tauopathies. Here, we determine how motifs controlling conformational changes in th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lathuilière, Aurélien, Valdés, Pamela, Papin, Stéphanie, Cacquevel, Matthias, Maclachlan, Catherine, Knott, Graham W., Muhs, Andreas, Paganetti, Paolo, Schneider, Bernard L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5648870/ https://www.ncbi.nlm.nih.gov/pubmed/29051562 http://dx.doi.org/10.1038/s41598-017-13786-2

Ejemplares similares

Deciphering the role of tau in neurodegeneration using Adeno-Associated Viral (AAV) vectors to express human tau in the mouse forebrain
por: Lathuilière, Aurélien, et al.
Publicado: (2013)

Emerging Evidences for an Implication of the Neurodegeneration-Associated Protein TAU in Cancer
por: Papin, Stéphanie, et al.
Publicado: (2020)

Tau K321/K353 pseudoacetylation within KXGS motifs regulates tau–microtubule interactions and inhibits aggregation
por: Xia, Yuxing, et al.
Publicado: (2021)

Quantitative Methods for the Detection of Tau Seeding Activity in Human Biofluids
por: Lathuiliere, Aurelien, et al.
Publicado: (2021)

Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology
por: Yang, Sujeong, et al.
Publicado: (2015)

Tau accumulation in degradative organelles is associated to lysosomal stress
por: Piovesana, Ester, et al.
Publicado: (2023)

The organization of microtubules and Tau in oligodendrocytes: Tau pathology in damaged oligodendrocytes
por: Torii, Tomohiro, et al.
Publicado: (2022)

Tau affects P53 function and cell fate during the DNA damage response
por: Sola, Martina, et al.
Publicado: (2020)

Phosphorylation of nuclear Tau is modulated by distinct cellular pathways
por: Ulrich, Giorgio, et al.
Publicado: (2018)

Tau Lysine Pseudomethylation Regulates Microtubule Binding and Enhances Prion-like Tau Aggregation
por: Xia, Yuxing, et al.
Publicado: (2023)

Encapsulated Cellular Implants for Recombinant Protein Delivery and Therapeutic Modulation of the Immune System
por: Lathuilière, Aurélien, et al.
Publicado: (2015)

Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance
por: Cook, Casey, et al.
Publicado: (2014)

Cancer-specific association between Tau (MAPT) and cellular pathways, clinical outcome, and drug response
por: Callari, Maurizio, et al.
Publicado: (2023)

Aggregation of Microtubule Binding Repeats of Tau Protein is Promoted by Cu(2+)
por: Ahmadi, Soha, et al.
Publicado: (2019)

Activated cofilin exacerbates tau pathology by impairing tau-mediated microtubule dynamics
por: Woo, Jung-A. A., et al.
Publicado: (2019)

Human tau pathology transmits glial tau aggregates in the absence of neuronal tau
por: Narasimhan, Sneha, et al.
Publicado: (2019)

Tau antibody 77G7 targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation
por: Li, Longfei, et al.
Publicado: (2022)

Aggregation, Transmission, and Toxicity of the Microtubule-Associated Protein Tau: A Complex Comprehension
por: Hu, Jiaxin, et al.
Publicado: (2023)

Tau protein binds to the P53 E3 ubiquitin ligase MDM2
por: Sola, Martina, et al.
Publicado: (2023)

Tau local structure shields an amyloid-forming motif and controls aggregation propensity
por: Chen, Dailu, et al.
Publicado: (2019)

Amyloid-β plaque deposition measured using propagation-based X-ray phase contrast CT imaging
por: Astolfo, Alberto, et al.
Publicado: (2016)

Tau protein modulates an epigenetic mechanism of cellular senescence in human SH-SY5Y neuroblastoma cells
por: Magrin, Claudia, et al.
Publicado: (2023)

Regulation of tau internalization, degradation, and seeding by LRP1 reveals multiple pathways for tau catabolism
por: Cooper, Joanna M., et al.
Publicado: (2021)

The microtubule binding domain of microtubule-associated protein MAP1B contains a repeated sequence motif unrelated to that of MAP2 and tau
Publicado: (1989)

Phosphorylation of the overlooked tyrosine 310 regulates the structure, aggregation, and microtubule- and lipid-binding properties of Tau
por: Ait-Bouziad, Nadine, et al.
Publicado: (2020)

CSF tau microtubule-binding region identifies pathological changes in primary tauopathies
por: Horie, Kanta, et al.
Publicado: (2022)

The microtubule-associated protein tau is phosphorylated by Syk
por: Lebouvier, Thibaud, et al.
Publicado: (2008)

Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation-induced pathology
por: Zhang, Shengnan, et al.
Publicado: (2022)

Identification of key amino acids responsible for the distinct aggregation properties of microtubule‐associated protein 2 and tau
por: Xie, Ce, et al.
Publicado: (2015)

Suppressing Tau Aggregation and Toxicity by an Anti-Aggregant Tau Fragment
por: Pir, Ghulam Jeelani, et al.
Publicado: (2018)

Specific detection of tau seeding activity in Alzheimer’s disease using rationally designed biosensor cells
por: Lathuiliere, Aurelien, et al.
Publicado: (2023)

Microtubules Gate Tau Condensation to Spatially Regulate Microtubule Functions
por: Tan, Ruensern, et al.
Publicado: (2019)

Retromer deficiency in Tauopathy models enhances the truncation and toxicity of Tau
por: Asadzadeh, Jamshid, et al.
Publicado: (2022)

Post-translational modifications within tau paired helical filament nucleating motifs perturb microtubule interactions and oligomer formation
por: Acosta, Diana M., et al.
Publicado: (2021)

Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy
por: Congdon, Erin E., et al.
Publicado: (2016)

Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates
por: Limorenko, Galina, et al.
Publicado: (2023)

Tau mutation S356T in the three repeat isoform leads to microtubule dysfunction and promotes prion-like seeded aggregation
por: Xia, Yuxing, et al.
Publicado: (2023)

Microtubule-binding core of the tau protein
por: El Mammeri, Nadia, et al.
Publicado: (2022)

Propagation of Tau aggregates
por: Goedert, Michel, et al.
Publicado: (2017)

Quantitative flow cytometric selection of tau conformational nanobodies specific for pathological aggregates
por: Zupancic, Jennifer M., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_a8lkvsqtrt0t2toatpsloi80u2